SWF1/YDR126W Summary Help

Standard Name SWF1 1
Systematic Name YDR126W
Alias PSL10
Feature Type ORF, Verified
Description Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion (1, 2, 3, 4)
Name Description Spore Wall Formation 1
Chromosomal Location
ChrIV:703234 to 704244 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SWF1 GO evidence and references
  View Computational GO annotations for SWF1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
Resources
242 total interaction(s) for 182 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Co-purification: 1
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 171
  • Phenotypic Enhancement: 2
  • Positive Genetic: 11
  • Synthetic Growth Defect: 31
  • Synthetic Lethality: 22
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 336
Molecular Weight (Da) 39,311
Isoelectric Point (pI) 7.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:703234 to 704244 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1011 703234..704244 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002533
References cited on this page View Complete Literature Guide for SWF1
1) Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54
2) Valdez-Taubas J and Pelham H  (2005) Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J 24(14):2524-32
3) Smotrys JE, et al.  (2005) The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J Cell Biol 170(7):1091-9
4) Gonzalez Montoro A, et al.  (2011) Specificity of transmembrane protein palmitoylation in yeast. PLoS One 6(2):e16969