Standard Name	SWD3 1
Systematic Name	YBR175W
Alias	CPS30 2 , SAF35 3
Feature Type	ORF, Verified
Description	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 (1, 2, 3, 4, 5, 6)
Name Description	Set1c, WD40 repeat protein

Chromosomal Location	ChrII:582408 to 583355 | ORF Map | GBrowse

	View Computational GO annotations for SWD3
Molecular Function
Manually curated	contributes_to histone methyltransferase activity (H3-K4 specific) (IDA, IMP)
Biological Process
Manually curated	chromatin silencing at telomere (IMP) histone H3-K4 methylation (IDA, IMP) telomere maintenance (IMP)
Cellular Component
Manually curated	Set1C/COMPASS complex (IPI)

Classical genetics
null	chronological lifespan: decreased fermentative metabolism: increased flocculation: increased H3K4 modification: decreased resistance to sirolimus: increased resistance to formamide: decreased resistance to chlorpromazine: decreased resistance to sirolimus: decreased utilization of carbon source: increased viable
Large-scale survey
null	UV resistance: decreased auxotrophy competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased resistance to nordihydroguaiaretic acid: decreased resistance to chlorpromazine: decreased resistance to sirolimus: increased resistance to sodium arsenite: decreased resistance to wortmannin: normal resistance to isopropyl (N-3-chloro-phenyl)-carbamate: decreased sporulation: abnormal sporulation efficiency: decreased starvation resistance: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	422 total interaction(s) for 243 unique genes/features.
Physical Interactions	Affinity Capture-MS: 53 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 Biochemical Activity: 4 Co-crystal Structure: 1 Co-purification: 2 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 215 Phenotypic Enhancement: 4 Phenotypic Suppression: 2 Positive Genetic: 39 Synthetic Growth Defect: 48 Synthetic Lethality: 38 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:582408 to 583355 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..948 582408..583355 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000379