Standard Name	SWC5 1
Systematic Name	YBR231C
Alias	AOR1 2
Feature Type	ORF, Verified
Description	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia (2, 3, 4, 5, 6)
Name Description	SWr Complex 1

Chromosomal Location	ChrII:683090 to 682179 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SWC5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin remodeling (IDA, IPI) histone exchange (IMP)
High-throughput	chromatin remodeling (IGI)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA) Swr1 complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal resistance to benomyl: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	bud morphology: abnormal budding index: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased haploproficient heat sensitivity: increased metal resistance: decreased resistance to caffeine: decreased resistance to benomyl: decreased resistance to arsenite(3-): decreased resistance to methyl methanesulfonate: decreased resistance to ethanol: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to streptomycin: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to fluconazole: decreased resistance to sodium selenide: decreased resistance to flubendazole: decreased resistance to Calcofluor White: decreased resistance to doxorubicin: decreased sporulation: normal sporulation efficiency: increased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	716 total interaction(s) for 395 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 2
Genetic Interactions	Negative Genetic: 310 Phenotypic Enhancement: 87 Phenotypic Suppression: 23 Positive Genetic: 63 Synthetic Growth Defect: 109 Synthetic Lethality: 62 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:683090 to 682179 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..912 683090..682179 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000435