SWC4/YGR002C Summary Help

Standard Name SWC4 1
Systematic Name YGR002C
Alias EAF2 2 , GOD1
Feature Type ORF, Verified
Description Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex (2, 3, 4, 5, 6)
Name Description SWr Complex
Chromosomal Location
ChrVII:499906 to 498476 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SWC4 GO evidence and references
  View Computational GO annotations for SWC4
Molecular Function
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
null
reduction of function
repressible
Large-scale survey
conditional
null
overexpression
repressible
Resources
344 total interaction(s) for 210 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 93
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 23
  • Co-crystal Structure: 2
  • Co-purification: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 3
  • Synthetic Growth Defect: 107
  • Synthetic Lethality: 106
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 476
Molecular Weight (Da) 55,212
Isoelectric Point (pI) 10.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:499906 to 498476 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1431 499906..498476 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003234
References cited on this page View Complete Literature Guide for SWC4
1) Schaft, D, et al.  (2002) personal communication
2) Nourani A, et al.  (2003) Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278(21):19171-5
3) Eisen A, et al.  (2001) The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem 276(5):3484-91
4) Nourani A, et al.  (2001) Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol 21(22):7629-40
5) Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76
6) Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8