SWC3/YAL011W Summary Help

SWC3 BASIC INFORMATION

Standard Name SWC3 1
Systematic Name YAL011W
Alias SWC1
Feature Type ORF, Verified
Description Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae (2, 3, 4)
Name Description SWr Complex
GO Annotations All SWC3 GO evidence and references
    View Computational GO annotations for SWC3
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SWC3 Phenotype details and references
Large-scale survey
null
Interactions SWC3 All interactions details and references
298 total interaction(s) for 185 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 28
  • Affinity Capture-Western: 2
  • Two-hybrid: 6
Genetic Interactions
  • Phenotypic Enhancement: 120
  • Phenotypic Suppression: 18
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 111
Sequence Information
ChrI:132202 to 134079 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1878 132202..134079 2004-07-20 2003-09-22
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000009

SWC3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SWC3

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
ALR1Nomenclature conflictSWC3 has been used to refer to both SWC3/YAL011W, whose gene product is involved in chromatin remodeling and ER biogenesis, and ALR1/YOL130W, a plasma membrane transporter.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SWC3]

1) Schaft, D, et al.  (2002) personal communication
2) Wright R, et al.  (2003) Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis. Yeast 20(10):881-92
3) Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76
4) Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8