SUS1/YBR111W-A Summary Help

Standard Name SUS1 1
Systematic Name YBR111W-A
Feature Type ORF, Verified
Description Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP (1, 2, 3, 4, 5, 6, 7)
Name Description Sl gene Upstream of ySa1 1
Chromosomal Location
ChrII:462139 to 462579 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SUS1 GO evidence and references
  View Computational GO annotations for SUS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
466 total interaction(s) for 302 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 182
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 47
  • Biochemical Activity: 4
  • Co-crystal Structure: 1
  • PCA: 2
  • Reconstituted Complex: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 174
  • Phenotypic Enhancement: 1
  • Positive Genetic: 33
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 8
  • Synthetic Rescue: 2

Resources
Length (a.a.) 96
Molecular Weight (Da) 11,084
Isoelectric Point (pI) 4.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:462139 to 462579 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-12-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..71 462139..462209 2011-02-03 2003-12-17
Intron 72..151 462210..462289 2011-02-03 2003-12-17
CDS 152..291 462290..462429 2011-02-03 2003-12-17
Intron 292..361 462430..462499 2011-02-03 2003-12-17
CDS 362..441 462500..462579 2011-02-03 2003-12-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000028510
References cited on this page View Complete Literature Guide for SUS1
1) Rodriguez-Navarro S, et al.  (2004) Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell 116(1):75-86
2) Cabal GG, et al.  (2006) SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope. Nature 441(7094):770-3
3) Kohler A, et al.  (2006) The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. Mol Biol Cell 17(10):4228-36
4) Gonzalez-Aguilera C, et al.  (2008) The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol Biol Cell 19(10):4310-8
5) Pascual-Garcia P, et al.  (2008) Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. Genes Dev 22(20):2811-22
6) Chekanova JA, et al.  (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77
7) Tous C, et al.  (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64