Standard Name	SUR7
Systematic Name	YML052W
Feature Type	ORF, Verified
Description	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants (1, 2, 3, 4)

Chromosomal Location	ChrXIII:170402 to 171310 | ORF Map | GBrowse

	View Computational GO annotations for SUR7
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ascospore formation (IMP) endocytosis (IGI, IMP)
Cellular Component
Manually curated	NOT actin cortical patch (IDA) cell cortex (IDA) eisosome (IDA) integral to membrane (ISS) membrane raft (IDA) plasma membrane (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
null	sphingolipid accumulation: abnormal sporulation efficiency: decreased
overexpression	nuclear morphology: abnormal resistance to hydroxyurea: decreased resistance to nocodazole: decreased
Large-scale survey
null	UV resistance: decreased hyperosmotic stress resistance: decreased resistance to hydroxyurea: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to sirolimus: increased resistance to bleomycin: decreased resistance to fenpropimorph: decreased resistance to methyl methanesulfonate: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	cell cycle progression: abnormal resistance to sirolimus: decreased vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	53 total interaction(s) for 50 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Co-fractionation: 3 Co-localization: 2 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 36 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:170402 to 171310 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..909 170402..171310 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004516