SUC1 Summary Help

Standard Name SUC1
Feature Type not in systematic sequence of S288C
Description Invertase; sucrose hydrolyzing enzyme; seven closely related but non-identical invertase genes have been described in yeast (SUC1-5, 7, 8) but only SUC2 is in the reference strain (S288C) (1, 2, 3, 4, 5 and see Summary Paragraph)
Chromosomal Location
ChrVII
Genetic position: 228 cM
Gene Ontology Annotations All SUC1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
sequence information
ChrVII
Genetic position: 228 cM
Resources
External Links Search all NCBI (Entrez)
Primary SGDIDS000029531
SUMMARY PARAGRAPH for SUC1

The S. cerevisiae genome contains seven unlinked loci that encode invertase: SUC1, SUC2, SUC3, SUC4, SUC5, SUC7, and SUC8 (3, 5). This enzyme, also known as "beta-fructofuranosidase," "beta-fructosidase," or "sucrase," plays an important role in sugar metabolism. Invertase catalyzes the hydrolysis of both the disaccharide sucrose (producing the monosaccharides fructose and glucose) and the trisaccharide raffinose (producing fructose and melibiose) (4, 6). All invertase genes except SUC2 are located within telomere sequences (7). Although individual strains may carry any number and combination of SUC genes, the reference strain (S288C) encodes only SUC2 (3) and most recent studies on invertase have focused on that gene.

Invertase played a notable role in early research on basic enzyme function. The colloquial name "invertase" comes from the fact that a solution of sucrose polarizes light in the opposite direction from an equimolar solution of glucose + fructose. This "inversion" of sugar provided a straightforward functional assay which, along with the easy preparation of a periplasmic protein (8 and references therein), made invertase a popular research subject among early biochemists. Many seminal works defining and describing enzymes, including those of Adrian Brown (9) and Leonor Michaelis and Maude Menton (10), focused on invertase.

Invertase also has a role in the food industry where it is used to produce fructose for use in confectionary. Fructose is often preferred over sucrose in candies with soft centers, as it is sweeter and less prone to crystallization (11).

Last updated: 2007-05-22 Contact SGD

References cited on this page View Complete Literature Guide for SUC1
1) Rodriguez L, et al.  (1981) SUC1 gene of Saccharomyces: a structural gene for the large (glycoprotein) and small (carbohydrate-free) forms of invertase. Mol Cell Biol 1(5):469-74
2) Hohmann S and Zimmermann FK  (1986) Cloning and expression on a multicopy vector of five invertase genes of Saccharomyces cerevisiae. Curr Genet 11(3):217-25
3) Carlson M and Botstein D  (1983) Organization of the SUC gene family in Saccharomyces. Mol Cell Biol 3(3):351-9
4) Gascon S, et al.  (1968) Comparative study of the properties of the purified internal and external invertases from yeast. J Biol Chem 243(7):1573-7
5) Naumov GI and Naumova ES  (2010) [Comparative genetics of yeasts: a novel beta-fructosidase gene SUC8 in Saccharomyces cerevisiae] Genetika 46(3):364-72
6) Taussig R and Carlson M  (1983) Nucleotide sequence of the yeast SUC2 gene for invertase. Nucleic Acids Res 11(6):1943-54
7) Carlson M, et al.  (1985) Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres. Mol Cell Biol 5(11):2894-902
8) O'Sullivan C and Tompson F  (1890) LX.-Invertase: a contribution to the history of an enzyme or unorganised ferment J Chem Soc Trans 57:834-931
9) Brown A  (1902) Enzyme action J Chem Soc Trans 81:373-388
10) Michaelis L and Menten M  (1913) Kinetik der Invertinwirkung Biochem Z 49:333-369
11) Smith J and Hong-Shum L  (2003) Food Additives Data Book :432