Standard Name	SUB2
Systematic Name	YDL084W
Feature Type	ORF, Verified
Description	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	SUppressor of Brr1-1

Chromosomal Location	ChrIV:305237 to 306577 | ORF Map | GBrowse

	View Computational GO annotations for SUB2
Molecular Function
Manually curated	ATP-dependent RNA helicase activity (IGI, ISA)
Biological Process
Manually curated	chromatin silencing at telomere (IMP) mRNA 3'-end processing (IMP) mRNA export from nucleus (IDA, IMP, IPI) mRNA splicing, via spliceosome (IMP) transcription elongation from RNA polymerase II promoter (IMP) transcription-coupled nucleotide-excision repair (IMP)
Cellular Component
Manually curated	chromosome, telomeric region (IPI) spliceosomal complex (TAS) transcription export complex (IPI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	mRNAs accumulation: decreased inviable mitotic recombination: increased vegetative growth: decreased
reduction of function	growth in exponential phase: decreased rate
repressible	unspliced pre-RNA accumulation: decreased
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	cell cycle progression: abnormal vegetative growth: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	182 total interaction(s) for 94 unique genes/features.
Physical Interactions	Affinity Capture-MS: 60 Affinity Capture-RNA: 3 Affinity Capture-Western: 21 Co-purification: 1 Reconstituted Complex: 5 Two-hybrid: 9
Genetic Interactions	Dosage Growth Defect: 17 Dosage Lethality: 2 Dosage Rescue: 13 Negative Genetic: 23 Phenotypic Enhancement: 1 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 17 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:305237 to 306577 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1341 305237..306577 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002242