Standard Name	SUB1 1
Systematic Name	YMR039C
Alias	TSP1
Feature Type	ORF, Verified
Description	Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ); role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress (2, 3, 4, 5, 6)
Name Description	SUppressor of TFIIB mutations 1

Chromosomal Location	ChrXIII:349522 to 348644 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SUB1
Molecular Function
Manually curated	transcription coactivator activity (IGI, IPI, ISS)
Biological Process
Manually curated	double-strand break repair via nonhomologous end joining (IMP) hyperosmotic response (IGI) positive regulation of transcription elongation from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IGI, IPI) positive regulation of transcription from RNA polymerase III promoter (IDA, IGI, IMP) regulation of transcription from RNA polymerase II promoter (ISS) regulation of transcription from RNA polymerase II promoter in response to stress (IDA, IGI, IMP) RNA polymerase III transcriptional preinitiation complex assembly (IDA) termination of RNA polymerase II transcription (IGI)
Cellular Component
Manually curated	nucleus (IC)
High-throughput	nucleus (IDA)

Classical genetics
null	SUP4 tRNA accumulation: decreased chronological lifespan: increased heat sensitivity: increased mutation frequency: increased FCP1 accumulation: decreased RNAP II modification: abnormal resistance to hydrogen peroxide: decreased viable
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to arsenite(3-): decreased resistance to acetic acid: decreased resistance to sulfanilamide: decreased sporulation efficiency: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	231 total interaction(s) for 180 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 3 Affinity Capture-Western: 3 Biochemical Activity: 3 Co-localization: 4 Far Western: 4 Reconstituted Complex: 5 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 5 Negative Genetic: 123 Phenotypic Enhancement: 19 Phenotypic Suppression: 5 Positive Genetic: 14 Synthetic Growth Defect: 24 Synthetic Lethality: 6 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:349522 to 348644 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..879 349522..348644 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004642