SUB1/YMR039C Summary

SUB1 BASIC INFORMATION

Standard Name	SUB1 1
Systematic Name	YMR039C
Alias	TSP1
Feature Type	ORF, Verified
Description	Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes (2, 3, 4)
Name Description	SUppressor of TFIIB mutations 1

GO Annotations	All SUB1 GO evidence and references
	View Computational GO annotations for SUB1
Molecular Function
Manually curated	transcription coactivator activity (IGI, IPI, ISS)
Biological Process
Manually curated	hyperosmotic response (IGI) positive regulation of RNA elongation from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IGI, IPI, ISS) positive regulation of transcription from RNA polymerase III promoter (IDA, IGI, IMP) regulation of transcription from RNA polymerase II promoter in response to stress (IDA, IGI, IMP) RNA polymerase III transcriptional preinitiation complex assembly (IDA) termination of RNA polymerase II transcription (IGI)
Cellular Component
Manually curated	nucleus (IC)

Mutant Phenotype	All SUB1 Phenotype details and references
Classical genetics
null	SUP4 tRNA accumulation: decreased mutation frequency: increased FCP1 accumulation: decreased RNAP II modification: abnormal resistance to hydrogen peroxide: decreased viable
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased resistance to sulfanilamide: decreased resistance to arsenite(3-): decreased viable

Interactions	SUB1 All interactions details and references
	View additional details at BioGRID
	141 total interaction(s) for 124 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 3 Far Western: 4 Reconstituted Complex: 3
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 66 Phenotypic Enhancement: 17 Phenotypic Suppression: 4 Positive Genetic: 9 Synthetic Growth Defect: 15 Synthetic Lethality: 5 Synthetic Rescue: 4

Sequence Information

ChrXIII:349521 to 348643 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..879	349521..348643	1996-07-31	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004642

SUB1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SUB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SUB1]

1)	Knaus R, et al. (1996) Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4. EMBO J 15(8):1933-40
2)	Wang JY, et al. (2004) The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage. Mol Cell Biol 24(13):6084-93
3)	Calvo O and Manley JL (2005) The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription. EMBO J 24(5):1009-20
4)	Rosonina E, et al. (2009) Sub1 Functions in Osmoregulation and in Transcription by both RNA Polymerases II and III. Mol Cell Biol 29(8):2308-21

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