STU2/YLR045C Summary Help

Standard Name STU2
Systematic Name YLR045C
Feature Type ORF, Verified
Description Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p (1, 2, 3, 4)
Name Description Suppressor of tub2
Chromosomal Location
ChrXII:237703 to 235037 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All STU2 GO evidence and references
  View Computational GO annotations for STU2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
overexpression
Resources
162 total interaction(s) for 113 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 12
  • Biochemical Activity: 2
  • Co-crystal Structure: 2
  • Co-purification: 1
  • PCA: 7
  • Reconstituted Complex: 5
  • Two-hybrid: 28

Genetic Interactions
  • Negative Genetic: 77
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 10
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 888
Molecular Weight (Da) 100,917
Isoelectric Point (pI) 9.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:237703 to 235037 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2667 237703..235037 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004035
References cited on this page View Complete Literature Guide for STU2
1) Chen XP, et al.  (1998) The yeast spindle pole body component Spc72p interacts with Stu2p and is required for proper microtubule assembly. J Cell Biol 141(5):1169-79
2) Wang PJ and Huffaker TC  (1997) Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body. J Cell Biol 139(5):1271-80
3) Severin F, et al.  (2001) Stu2 promotes mitotic spindle elongation in anaphase. J Cell Biol 153(2):435-42
4) Kosco KA, et al.  (2001) Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol Biol Cell 12(9):2870-80