STP4/YDL048C Summary Help

Standard Name STP4 1
Systematic Name YDL048C
Feature Type ORF, Verified
Description Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description protein with similarity to Stp1p 2
Chromosomal Location
ChrIV:368211 to 366739 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All STP4 GO evidence and references
  View Computational GO annotations for STP4
Molecular Function
Biological Process
Manually curated
Cellular Component
Regulators 15 genes
Large-scale survey
30 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 15
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 490
Molecular Weight (Da) 54,366
Isoelectric Point (pI) 9.47
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:368211 to 366739 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2004-02-11 | Sequence: 1999-02-09
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1473 368211..366739 2004-02-11 1999-02-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002206
References cited on this page View Complete Literature Guide for STP4
1) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
2) Abdel-Sater F, et al.  (2004) The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae. Genetics 166(4):1727-39
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Yang Y, et al.  (2010) Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Cell Res 20(11):1276-8
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66