STO1/YMR125W Summary Help

Standard Name STO1
Systematic Name YMR125W
Alias CBC1 1 , GCR3 , CBP80 , SUT1
Feature Type ORF, Verified
Description Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 (1, 2, 3, 4, 5, 6)
Name Description Suppressor of top1
Chromosomal Location
ChrXIII:517539 to 520446 | ORF Map | GBrowse
Gbrowse
Genetic position: 87 cM
Gene Ontology Annotations All STO1 GO evidence and references
  View Computational GO annotations for STO1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
360 total interaction(s) for 177 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 1
  • Affinity Capture-MS: 216
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 8
  • Co-localization: 8
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 43
  • Phenotypic Suppression: 1
  • Positive Genetic: 21
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 26
  • Synthetic Rescue: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 861
Molecular Weight (Da) 100,017
Isoelectric Point (pI) 4.64
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:517539 to 520446 | ORF Map | GBrowse
SGD ORF map
Genetic position: 87 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1999-11-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..25 517539..517563 2011-02-03 1999-11-17
Intron 26..347 517564..517885 2011-02-03 1999-11-17
CDS 348..2908 517886..520446 2011-02-03 1999-11-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004732
References cited on this page View Complete Literature Guide for STO1
1) Das B, et al.  (2000) The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation. Mol Cell Biol 20(8):2827-38
2) Fortes P, et al.  (1999) Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol 19(10):6543-53
3) Lewis JD, et al.  (1996) A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res 24(17):3332-6
4) Das B, et al.  (2003) Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae. Mol Cell Biol 23(16):5502-15
5) Gao Q, et al.  (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A 102(12):4258-63
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63