STN1/YDR082W Summary Help

Standard Name STN1 1
Systematic Name YDR082W
Feature Type ORF, Verified
Description Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; similar to human Stn1 (2, 3)
Name Description Suppressor of cdc ThirteeN 1
Chromosomal Location
ChrIV:610441 to 611925 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All STN1 GO evidence and references
  View Computational GO annotations for STN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
reduction of function
Resources
84 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 8
  • Co-fractionation: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 27

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Negative Genetic: 2
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 10
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 494
Molecular Weight (Da) 57,510
Isoelectric Point (pI) 5.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:610441 to 611925 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1485 610441..611925 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002489
References cited on this page View Complete Literature Guide for STN1
1) Grandin N, et al.  (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev 11(4):512-27
2) Grossi S, et al.  (2004) Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev 18(9):992-1006
3) Bryan C, et al.  (2013) Structure of the human telomeric stn1-ten1 capping complex. PLoS One 8(6):e66756