STI1/YOR027W Summary Help

Standard Name STI1 1
Systematic Name YOR027W
Feature Type ORF, Verified
Description Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop (1, 2, 3, 4, 5)
Name Description STress Inducible 1
Chromosomal Location
ChrXV:381053 to 382822 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All STI1 GO evidence and references
  View Computational GO annotations for STI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 13 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
194 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 41
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 25
  • Co-crystal Structure: 3
  • Co-purification: 1
  • PCA: 4
  • Reconstituted Complex: 21
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 43
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 21

Resources
Expression Summary
histogram
Resources
Length (a.a.) 589
Molecular Weight (Da) 66,264
Isoelectric Point (pI) 5.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:381053 to 382822 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1770 381053..382822 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005553
References cited on this page View Complete Literature Guide for STI1
1) Nicolet CM and Craig EA  (1989) Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae. Mol Cell Biol 9(9):3638-46
2) Chang HC, et al.  (1997) In vivo analysis of the Hsp90 cochaperone Sti1 (p60). Mol Cell Biol 17(1):318-25
3) Richter K, et al.  (2003) Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle. J Biol Chem 278(12):10328-33
4) Wegele H, et al.  (2003) Sti1 is a novel activator of the Ssa proteins. J Biol Chem 278(28):25970-6
5) Li J, et al.  (2011) Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. Nat Struct Mol Biol 18(1):61-6