STH1/YIL126W Summary

STH1 BASIC INFORMATION

Standard Name	STH1
Systematic Name	YIL126W
Alias	NPS1
Feature Type	ORF, Verified
Description	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p (1, 2, 3, 4)
Name Description	SNF2 (Two) Homolog

GO Annotations	All STH1 GO evidence and references
	View Computational GO annotations for STH1
Molecular Function
Manually curated	ATPase activity (IDA) contributes_to DNA-dependent ATPase activity (IDA) DNA-dependent ATPase activity (IDA) helicase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) chromatin remodeling at centromere (IMP) chromosome segregation (IGI) cytoskeleton organization (IGI, IMP) double-strand break repair (IMP) G2/M transition of mitotic cell cycle (IMP) meiosis (IMP) nucleosome disassembly (IDA) regulation of transcription (IMP) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Mutant Phenotype	All STH1 Phenotype details and references
Classical genetics
repressible	Pmp2GFP-KKTN distribution: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable resistance to sulfanilamide: decreased
repressible	Pmp2GFP-LRKR distribution: decreased

Interactions	STH1 All interactions details and references
	195 total interaction(s) for 70 unique genes/features.
Physical Interactions	Affinity Capture-MS: 96 Affinity Capture-Western: 41 Co-purification: 13 Far Western: 3 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 11 Phenotypic Enhancement: 1 Synthetic Growth Defect: 13 Synthetic Lethality: 6 Synthetic Rescue: 4

Sequence Information

ChrIX:117992 to 122071 | |

Genetic position: -91 cM

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4080	117992..122071	1994-12-10	1994-12-10

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001388

STH1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for STH1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for STH1]

1)	Laurent BC, et al. (1992) An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family. Mol Cell Biol 12(4):1893-902
2)	Yukawa M, et al. (1999) Nps1/Sth1p, a component of an essential chromatin-remodeling complex of Saccharomyces cerevisiae, is required for the maximal expression of early meiotic genes. Genes Cells 4(2):99-110
3)	Du J, et al. (1998) Sth1p, a Saccharomyces cerevisiae Snf2p/Swi2p homolog, is an essential ATPase in RSC and differs from Snf/Swi in its interactions with histones and chromatin-associated proteins. Genetics 150(3):987-1005
4)	Hsu JM, et al. (2003) The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol 23(9):3202-15

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