STH1/YIL126W Summary Help

Standard Name STH1 1
Systematic Name YIL126W
Alias NPS1 2
Feature Type ORF, Verified
Description ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p (1, 3, 4, 5, 6)
Name Description SNF Two Homolog 1
Chromosomal Location
ChrIX:117992 to 122071 | ORF Map | GBrowse
Gbrowse
Genetic position: -91 cM
Gene Ontology Annotations All STH1 GO evidence and references
  View Computational GO annotations for STH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Classical genetics
conditional
null
repressible
Large-scale survey
conditional
null
reduction of function
repressible
Resources
254 total interaction(s) for 91 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 120
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 46
  • Co-fractionation: 1
  • Co-purification: 13
  • Far Western: 3
  • Reconstituted Complex: 9
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 19
  • Negative Genetic: 3
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 17
  • Synthetic Lethality: 8
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,359
Molecular Weight (Da) 156,741
Isoelectric Point (pI) 6.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:117992 to 122071 | ORF Map | GBrowse
SGD ORF map
Genetic position: -91 cM
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4080 117992..122071 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001388
References cited on this page View Complete Literature Guide for STH1
1) Laurent BC, et al.  (1992) An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family. Mol Cell Biol 12(4):1893-902
2) Tsuchiya E, et al.  (1992) The Saccharomyces cerevisiae NPS1 gene, a novel CDC gene which encodes a 160 kDa nuclear protein involved in G2 phase control. EMBO J 11(11):4017-26
3) Yukawa M, et al.  (1999) Nps1/Sth1p, a component of an essential chromatin-remodeling complex of Saccharomyces cerevisiae, is required for the maximal expression of early meiotic genes. Genes Cells 4(2):99-110
4) Du J, et al.  (1998) Sth1p, a Saccharomyces cerevisiae Snf2p/Swi2p homolog, is an essential ATPase in RSC and differs from Snf/Swi in its interactions with histones and chromatin-associated proteins. Genetics 150(3):987-1005
5) Hsu JM, et al.  (2003) The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol 23(9):3202-15
6) Czaja W, et al.  (2014) Chromatin remodelling complex RSC promotes base excision repair in chromatin of Saccharomyces cerevisiae. DNA Repair (Amst) 16C():35-43