STF2/YGR008C Summary Help

Standard Name STF2 1
Systematic Name YGR008C
Feature Type ORF, Verified
Description Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description STabilizing Factor 7, 8
Chromosomal Location
ChrVII:508364 to 508110 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All STF2 GO evidence and references
  View Computational GO annotations for STF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 15 genes
Classical genetics
Large-scale survey
15 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 3
  • PCA: 4

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 84
Molecular Weight (Da) 9,615
Isoelectric Point (pI) 9.08
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:508364 to 508110 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..255 508364..508110 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003240
References cited on this page View Complete Literature Guide for STF2
1) Yoshida Y, et al.  (1990) Isolation of a gene for a regulatory 15-kDa subunit of mitochondrial F1F0-ATPase and construction of mutant yeast lacking the protein. Eur J Biochem 192(1):49-53
2) Dienhart M, et al.  (2002) Formation of the yeast F1F0-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. J Biol Chem 277(42):39289-95
3) Hashimoto T, et al.  (1990) Simultaneous bindings of ATPase inhibitor and 9K protein to F1F0-ATPase in the presence of 15K protein in yeast mitochondria. J Biochem 108(1):17-20
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Lopez-Martinez G, et al.  (2012) The STF2p Hydrophilin from Saccharomyces cerevisiae Is Required for Dehydration Stress Tolerance. PLoS One 7(3):e33324
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Hashimoto T, et al.  (1983) Binding properties of an intrinsic ATPase inhibitor and occurrence in yeast mitochondria of a protein factor which stabilizes and facilitates the binding of the inhibitor to F1F0-ATPase. J Biochem 94(3):715-20
8) Hashimoto T, et al.  (1984) Purification and properties of factors in yeast mitochondria stabilizing the F1F0-ATPase-inhibitor complex. J Biochem 95(1):131-6