Standard Name	STE24
Systematic Name	YJR117W
Alias	AFC1 1 , PIO2
Feature Type	ORF, Verified
Description	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans (1, 2, 3, 4)
Name Description	STErile

Chromosomal Location	ChrX:642007 to 643368 | ORF Map | GBrowse

	View Computational GO annotations for STE24
Molecular Function
Manually curated	metalloendopeptidase activity (IDA, IMP, ISS)
Biological Process
Manually curated	CAAX-box protein processing (IMP) peptide pheromone maturation (IDA, IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA) nuclear inner membrane (IMP)
High-throughput	integral to membrane (ISM) mitochondrial outer membrane (IDA)

Classical genetics
null	mating response: decreased metal resistance: decreased pheromone production: decreased viable
overexpression	nuclear morphology: abnormal
Large-scale survey
null	anaerobic growth: decreased competitive fitness: increased haploinsufficient protein transport: abnormal resistance to amitrole: decreased resistance to neomycin: decreased resistance to cycloheximide: decreased resistance to PM02734: increased resistance to cycloheximide: increased resistance to fenpropimorph: increased resistance to fluconazole: increased resistance to hydroxyurea: increased resistance to nickel sulfate: decreased resistance to tunicamycin: decreased resistance to caffeine: increased stress resistance: decreased toxin resistance: decreased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	382 total interaction(s) for 196 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 2 PCA: 43 Protein-RNA: 1 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 243 Phenotypic Enhancement: 16 Phenotypic Suppression: 30 Positive Genetic: 15 Synthetic Growth Defect: 17 Synthetic Lethality: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:642007 to 643368 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1362 642007..643368 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003878