STE23/YLR389C Summary Help

Standard Name STE23
Systematic Name YLR389C
Feature Type ORF, Verified
Description Metalloprotease; involved in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family; homolog Axl1p is also involved in processing of pro-a-factor (1, 2, 3)
Name Description STErile
Chromosomal Location
ChrXII:902660 to 899577 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All STE23 GO evidence and references
  View Computational GO annotations for STE23
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
Resources
13 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,027
Molecular Weight (Da) 117,578
Isoelectric Point (pI) 6.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:902660 to 899577 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-02-05 | Sequence: 2004-02-05
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3084 902660..899577 2004-02-05 2004-02-05
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004381
References cited on this page View Complete Literature Guide for STE23
1) Boyartchuk VL and Rine J  (1998) Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor. Genetics 150(1):95-101
2) Adames N, et al.  (1995) Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection. Science 270(5235):464-7
3) Alper BJ, et al.  (2009) Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes. Yeast 26(11):595-610