STD1/YOR047C Summary Help

Standard Name STD1 1
Systematic Name YOR047C
Alias MSN3 , SFS3
Feature Type ORF, Verified
Description Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description Suppressor of Tbp Deletion 1
Chromosomal Location
ChrXV:417681 to 416347 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All STD1 GO evidence and references
  View Computational GO annotations for STD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
70 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 3
  • Reconstituted Complex: 3
  • Two-hybrid: 33

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 7
  • Negative Genetic: 16
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 444
Molecular Weight (Da) 50,260
Isoelectric Point (pI) 9.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:417681 to 416347 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1335 417681..416347 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005573
References cited on this page View Complete Literature Guide for STD1
1) Ganster RW, et al.  (1993) Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein. Mol Cell Biol 13(6):3650-9
2) Tillman TS, et al.  (1995) STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae. Nucleic Acids Res 23(16):3174-80
3) Schmidt MC, et al.  (1999) Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(7):4561-71
4) Kaniak A, et al.  (2004) Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae. Eukaryot Cell 3(1):221-31
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Crow ET and Li L  (2011) Newly identified prions in budding yeast, and their possible functions. Semin Cell Dev Biol 22(5):452-9