STB1/YNL309W Summary Help

Standard Name STB1 1
Systematic Name YNL309W
Feature Type ORF, Verified
Description Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Sin Three Binding protein
Chromosomal Location
ChrXIV:52662 to 53924 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All STB1 GO evidence and references
  View Computational GO annotations for STB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulatory Role
Binding motifs Predicted STB1 Binding Site Locations
    Regulatory modules predicted: cellcycle (257)
    Resources
    Mutant phenotypes All STB1 Phenotype evidence and references
    Classical genetics
    null
    Large-scale survey
    null
    overexpression
    Resources
    interactions All STB1 Interaction evidence and references
    87 total interaction(s) for 71 unique genes/features.
    Physical Interactions
    • Affinity Capture-MS: 1
    • Affinity Capture-RNA: 1
    • Affinity Capture-Western: 3
    • Biochemical Activity: 4
    • Protein-RNA: 1
    • Reconstituted Complex: 1
    • Two-hybrid: 1
    Genetic Interactions
    • Negative Genetic: 62
    • Phenotypic Enhancement: 2
    • Positive Genetic: 2
    • Synthetic Growth Defect: 5
    • Synthetic Lethality: 1
    • Synthetic Rescue: 3
    Resources
    Expression Summary
    histogram
    Resources
    Protein Information All STB1 Protein evidence and references
    Localization
    Phosphorylation PhosphoGRID | PhosphoPep Database
    Structure
    Homologs
    sequence information
    ChrXIV:52662 to 53924 | ORF Map | GBrowse
    SGD ORF map
    Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
    Subfeature details
    Relative
    Coordinates    		 Chromosomal
    Coordinates    		 Most Recent Updates
    Coordinates Sequence
    CDS 1..1263 52662..53924 2011-02-03 2003-09-22
    Retrieve sequences
    Analyze Sequence
    S288C only
    S288C vs. other species
    S288C vs. other strains
    Resources
    External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
    Primary SGDIDS000005253
    References cited on this page View Complete Literature Guide for STB1
    1) Stillman, D.  (1993) Personal Communication, Mortimer Map Edition 12
    2) Ho Y, et al.  (1999) Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein. Mol Cell Biol 19(8):5267-78
    3) Costanzo M, et al.  (2003) G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1. Mol Cell Biol 23(14):5064-77
    4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
    5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
    6) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104