Standard Name	SSU72 1
Systematic Name	YNL222W
Feature Type	ORF, Verified
Description	Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo (1, 2, 3, 4)
Name Description	Suppressor of SUa7, gene 2 1

Chromosomal Location	ChrXIV:229094 to 229714 | ORF Map | GBrowse

	View Computational GO annotations for SSU72
Molecular Function
Manually curated	CTD phosphatase activity (IDA, IMP) phosphoprotein phosphatase activity (IGI) protein serine/threonine phosphatase activity (IDA, IMP) protein tyrosine phosphatase activity (IDA, ISS)
Biological Process
Manually curated	dephosphorylation of RNA polymerase II C-terminal domain (IDA, IMP) mRNA 3'-end processing (IMP) mRNA cleavage (IMP) snoRNA transcription (IMP) termination of RNA polymerase II transcription (IMP) termination of RNA polymerase II transcription, exosome-dependent (IMP, IPI) termination of RNA polymerase II transcription, poly(A)-coupled (IMP, IPI) transcription antitermination (IMP) transcription elongation from RNA polymerase II promoter (IGI, IMP) transcription initiation from RNA polymerase II promoter (IGI, IPI) transcriptional start site selection at RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	mRNA cleavage and polyadenylation specificity factor complex (IDA, IPI) nucleus (IGI, IPI)

Classical genetics
conditional	heat sensitivity: increased Rpo21p modification: increased resistance to cordycepin: decreased
Large-scale survey
conditional	colony sectoring: increased
null	inviable
reduction of function	competitive fitness: increased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	236 total interaction(s) for 134 unique genes/features.
Physical Interactions	Affinity Capture-MS: 77 Affinity Capture-Western: 9 Protein-peptide: 1 Reconstituted Complex: 8 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 96 Phenotypic Enhancement: 2 Positive Genetic: 10 Synthetic Growth Defect: 5 Synthetic Lethality: 9 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:229094 to 229714 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..621 229094..229714 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005166