SSL1/YLR005W Summary Help

Standard Name SSL1 1
Systematic Name YLR005W
Feature Type ORF, Verified
Description Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p (2, 3, 4)
Name Description Suppressor of Stem-Loop mutation 1
Chromosomal Location
ChrXII:160049 to 161434 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SSL1 GO evidence and references
  View Computational GO annotations for SSL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
133 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-purification: 12
  • PCA: 1
  • Reconstituted Complex: 5

Genetic Interactions
  • Negative Genetic: 67
  • Phenotypic Suppression: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 4
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 461
Molecular Weight (Da) 52,290
Isoelectric Point (pI) 7.69
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:160049 to 161434 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1386 160049..161434 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003995
References cited on this page View Complete Literature Guide for SSL1
1) Gulyas KD and Donahue TF  (1992) SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3. Cell 69(6):1031-42
2) Feaver WJ, et al.  (1993) Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair. Cell 75(7):1379-87
3) Svejstrup JQ, et al.  (1996) The multiple roles of transcription/repair factor TFIIH. Trends Biochem Sci 21(9):346-50
4) Feaver WJ, et al.  (2000) Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair. J Biol Chem 275(8):5941-6