Standard Name	SSK2 1
Systematic Name	YNR031C
Feature Type	ORF, Verified
Description	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; SSK2 has a paralog, SSK22, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description	Suppressor of Sensor Kinase 1

Chromosomal Location	ChrXIV:685433 to 680694 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SSK2
Molecular Function
Manually curated	MAP kinase kinase kinase activity (IDA)
Biological Process
Manually curated	actin cytoskeleton organization (IDA) MAPK cascade involved in osmosensory signaling pathway (IMP) osmosensory signaling via phosphorelay pathway (IGI, IPI) protein autophosphorylation (IDA) protein phosphorylation (IDA) response to osmotic stress (IGI, IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytosol (IDA)

Classical genetics
null	metal resistance: decreased prion formation: decreased resistance to furfural: increased resistance to tunicamycin: decreased resistance to mercaptoethanol: decreased resistance to L-1,4-dithiothreitol: normal toxin resistance: increased
unspecified	resistance to caffeine: increased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased endocytosis: decreased filamentous growth: increased hyperosmotic stress resistance: decreased resistance to bleomycin: increased resistance to nickel(2+): increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to fenpropimorph: increased resistance to arsenite(3-): decreased resistance to hydrogen chloride: decreased resistance to sodium arsenite: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to benzo[a]pyrene: decreased transposable element transposition: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
unspecified	resistance to Calcofluor White: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	229 total interaction(s) for 170 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 4 Affinity Capture-Western: 4 Biochemical Activity: 4 PCA: 4 Reconstituted Complex: 12 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 12 Dosage Lethality: 2 Dosage Rescue: 6 Negative Genetic: 122 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Positive Genetic: 15 Synthetic Growth Defect: 6 Synthetic Haploinsufficiency: 2 Synthetic Lethality: 3 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:685433 to 680694 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4740 685433..680694 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005314