Standard Name	SSK1 1
Systematic Name	YLR006C
Feature Type	ORF, Verified
Description	Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate (2, 3, 4, 5)
Name Description	Suppressor of Sensor Kinase 1

Chromosomal Location	ChrXII:163893 to 161755 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SSK1
Molecular Function
Manually curated	mitogen-activated protein kinase kinase kinase binding (IPI) phosphorelay response regulator activity (IMP) protein homodimerization activity (IDA) protein kinase activator activity (IDA, IMP)
Biological Process
Manually curated	activation of MAPKKK activity involved in osmosensory signaling pathway (IGI, IMP) osmosensory signaling via phosphorelay pathway (IDA) positive regulation of protein autophosphorylation (IDA)
Cellular Component
Manually curated	cytoplasm (IDA)

Classical genetics
null	actin cytoskeleton morphology: abnormal metal resistance: decreased mitophagy: decreased resistance to Calcofluor White: increased resistance to cadmium chloride: decreased resistance to sodium dodecyl sulfate: decreased resistance to tunicamycin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: decreased
overexpression	cell size: increased cellular morphology: abnormal
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploinsufficient resistance to hydrogen chloride: decreased resistance to citric acid: decreased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to bleomycin: increased resistance to sodium arsenite: decreased resistance to methyl methanesulfonate: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to sodium selenide: decreased resistance to 2-coumaric acid: decreased sporulation efficiency: increased starvation resistance: decreased stress resistance: increased transposable element transposition: decreased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	114 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 8 Co-crystal Structure: 1 PCA: 6 Reconstituted Complex: 3 Two-hybrid: 9
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 1 Negative Genetic: 29 Phenotypic Enhancement: 7 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Growth Defect: 20 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:163893 to 161755 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2139 163893..161755 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003996