SSD1/YDR293C Summary 
| Standard Name | SSD1 1 (see Nomenclature conflict Note) |
|---|---|
| Systematic Name | YDR293C |
| Alias | CLA1 , MCS1 , RLT1 , SRK1 |
| Feature Type | ORF, Verified |
| Description | Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function (2, 3, 4, 5, 6, 7) |
| Name Description | Suppressor of SIT4 Deletion 1, 8 |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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| Genetic position: 176 cM |
Gene Ontology Annotations All SSD1 GO evidence and references
| View Computational GO annotations for SSD1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Mutant phenotypes All SSD1 Phenotype evidence and references
interactions All SSD1 Interaction evidence and references
| 697 total interaction(s) for 471 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All SSD1 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Genetic position: 176 cM | |||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000002701 |
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NOMENCLATURE CONFLICT NOTE
| Name | Relevance | Description |
|---|---|---|
| ZDS2 | Nomenclature conflict | MCS1 has been used to refer to both ZDS2/YML109W, whose gene product is involved in silencing, and SSD1/YDR293C, whose gene product is involved in cell wall integrity. |
References cited on this page View Complete Literature Guide for SSD1
| 1) | Sutton A, et al. (1991) The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11(4):2133-48 |
| 2) | Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 |
| 3) | Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 |
| 4) | Jansen JM, et al. (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20 |
| 5) | Ohyama Y, et al. (2010) Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA. Genes Cells 15(12):1169-88 |
| 6) | Kurischko C, et al. (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98 |
| 7) | Kurischko C, et al. (2011) Nucleocytoplasmic shuttling of Ssd1 defines the destiny of its bound mRNAs. Mol Microbiol 81(3):831-49 |
| 8) | Stettler S, et al. (1993) A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae. Mol Gen Genet 239(1-2):169-76 |
