SRX1/YKL086W Summary Help

Standard Name SRX1 1
Systematic Name YKL086W
Feature Type ORF, Verified
Description Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress (1, 2)
Name Description SulfiRedoXin 1
Chromosomal Location
ChrXI:278281 to 278664 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SRX1 GO evidence and references
  View Computational GO annotations for SRX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
6 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 127
Molecular Weight (Da) 13,854
Isoelectric Point (pI) 9.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:278281 to 278664 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..384 278281..278664 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001569
References cited on this page View Complete Literature Guide for SRX1
1) Biteau B, et al.  (2003) ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature 425(6961):980-4
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76