SRO9/YCL037C Summary Help

Standard Name SRO9 1
Systematic Name YCL037C
Feature Type ORF, Verified
Description Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Suppressor of rho3 1
Chromosomal Location
ChrIII:58678 to 57374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SRO9 GO evidence and references
  View Computational GO annotations for SRO9
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Large-scale survey
null
Resources
1037 total interaction(s) for 939 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 62
  • Affinity Capture-RNA: 810
  • Affinity Capture-Western: 14
  • Biochemical Activity: 1
  • PCA: 14

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Negative Genetic: 77
  • Positive Genetic: 23
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 10
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 434
Molecular Weight (Da) 48,060
Isoelectric Point (pI) 9.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:58678 to 57374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2003-09-22 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1305 58678..57374 2003-09-22 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000542
References cited on this page View Complete Literature Guide for SRO9
1) Kagami M, et al.  (1997) SRO9, a multicopy suppressor of the bud growth defect in the Saccharomyces cerevisiae rho3-deficient cells, shows strong genetic interactions with tropomyosin genes, suggesting its role in organization of the actin cytoskeleton. Genetics 147(3):1003-16
2) Sobel SG and Wolin SL  (1999) Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Mol Biol Cell 10(11):3849-62
3) Hon T, et al.  (2001) The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Mol Cell Biol 21(23):7923-32
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Rother S, et al.  (2010) Nucleocytoplasmic shuttling of the La motif-containing protein Sro9 might link its nuclear and cytoplasmic functions. RNA 16(7):1393-401