Standard Name	SRN2
Systematic Name	YLR119W
Alias	SRN10 , VPS37 1 , 2 , 3 , VPL16 2
Feature Type	ORF, Verified
Description	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus (3)
Name Description	Suppressor of rna1-1

Chromosomal Location	ChrXII:385534 to 386175 | ORF Map | GBrowse

	View Computational GO annotations for SRN2
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	protein targeting to membrane (IMP, IPI) protein targeting to vacuole (IMP, IPI) ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IC)
Cellular Component
Manually curated	endosome (IPI) ESCRT I complex (IDA, IPI)

Classical genetics
null	PTR2 mRNA accumulation: decreased hyperosmotic stress resistance: decreased Ptr2p-GFP distribution: abnormal resistance to 5-fluorouracil: decreased resistance to canavanine: decreased resistance to Calcofluor White: decreased resistance to sulfometuron: decreased small molecule transport: increased
reduction of function	vacuolar transport: abnormal
Large-scale survey
null	acid pH resistance: decreased inositol excretion: increased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploproficient heat sensitivity: increased ionic stress resistance: decreased nutrient utilization: increased Fus-Mid-GFP distribution: abnormal resistance to sirolimus: decreased resistance to acetic acid: increased resistance to (S)-lactic acid: increased resistance to nickel(2+): increased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to arsenite(3-): decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to dimethyl sulfoxide: decreased resistance to clioquinol: decreased resistance to wortmannin: normal resistance to 1,4-dithiothreitol: decreased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	194 total interaction(s) for 180 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Co-crystal Structure: 2 Co-purification: 2 Two-hybrid: 13
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 133 Phenotypic Suppression: 5 Positive Genetic: 14 Synthetic Growth Defect: 9 Synthetic Lethality: 1 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:385534 to 386175 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..642 385534..386175 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004109