Standard Name	SRM1 1
Systematic Name	YGL097W
Alias	MTR1 2 , PRP20 3
Feature Type	ORF, Verified
Description	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p (1, 4, 5, 6)
Name Description	Suppressor of Receptor Mutations 1

Chromosomal Location	ChrVII:321782 to 323230 | ORF Map | GBrowse

	View Computational GO annotations for SRM1
Molecular Function
Manually curated	signal transducer activity (IMP)
Biological Process
Manually curated	ribosomal subunit export from nucleus (IMP) rRNA export from nucleus (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) nucleus (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	poly(A)+ RNA accumulation: increased unspliced intron-containing RNA accumulation: abnormal heat sensitivity: increased nuclear export: decreased
overexpression	Sir3p distribution: abnormal Rap1p distribution: abnormal silencing: decreased
Large-scale survey
conditional	colony sectoring: increased
null	cell size: increased cell size: decreased haploinsufficient inviable
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	116 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 32 Affinity Capture-Western: 4 Biochemical Activity: 1 Co-fractionation: 1 Co-localization: 1 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 12 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 7 Negative Genetic: 29 Phenotypic Suppression: 2 Positive Genetic: 8 Synthetic Growth Defect: 1 Synthetic Lethality: 9 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:321782 to 323230 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1449 321782..323230 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003065