SRL1/YOR247W Summary Help

Standard Name SRL1 1
Systematic Name YOR247W
Feature Type ORF, Verified
Description Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication (2, 3, 4)
Name Description Suppressor of Rad53 null Lethality 1
Chromosomal Location
ChrXV:797676 to 798308 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SRL1 GO evidence and references
  View Computational GO annotations for SRL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 13 genes
Resources
Large-scale survey
null
overexpression
Resources
25 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 4
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 210
Molecular Weight (Da) 22,048
Isoelectric Point (pI) 4.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:797676 to 798308 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..633 797676..798308 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005773
References cited on this page View Complete Literature Guide for SRL1
1) Desany BA, et al.  (1998) Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev 12(18):2956-70
2) Terashima H, et al.  (2002) Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae. Curr Genet 40(5):311-6
3) Hagen I, et al.  (2004) Sed1p and Srl1p are required to compensate for cell wall instability in Saccharomyces cerevisiae mutants defective in multiple GPI-anchored mannoproteins. Mol Microbiol 52(5):1413-25
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61