SRC1/YML034W Summary Help

Standard Name SRC1 1
Systematic Name YML034W
Alias YML033W , HEH1 2
Feature Type ORF, Verified
Description Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Spliced mRNA and Cell cycle regulated gene 1
Chromosomal Location
ChrXIII:209525 to 212155 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SRC1 GO evidence and references
  View Computational GO annotations for SRC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All SRC1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All SRC1 Interaction evidence and references
283 total interaction(s) for 162 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-localization: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 210
  • Phenotypic Enhancement: 4
  • Positive Genetic: 10
  • Synthetic Growth Defect: 30
  • Synthetic Lethality: 6
Resources
Expression Summary
histogram
Resources
Protein Information All SRC1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:209525 to 212155 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1998-11-10 | Sequence: 1998-11-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1920 209525..211444 1998-11-10 1998-11-10
Intron 1921..2046 211445..211570 1998-11-10 1998-11-10
CDS 2047..2631 211571..212155 1998-11-10 1998-11-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004497
References cited on this page View Complete Literature Guide for SRC1
1) Rodriguez-Navarro S, et al.  (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54
2) King MC, et al.  (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Grund SE, et al.  (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910
7) Torres EM, et al.  (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83
8) Mishra SK, et al.  (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature ()