SQT1/YIR012W Summary Help

Standard Name SQT1
Systematic Name YIR012W
Feature Type ORF, Verified
Description Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress (1, 2)
Chromosomal Location
ChrIX:378486 to 379781 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SQT1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
25 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • PCA: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Positive Genetic: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 431
Molecular Weight (Da) 47,167
Isoelectric Point (pI) 4.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:378486 to 379781 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1296 378486..379781 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001451
References cited on this page View Complete Literature Guide for SQT1
1) Eisinger DP, et al.  (1997) SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1. Mol Cell Biol 17(9):5146-55
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76