SPP381/YBR152W Summary Help

Standard Name SPP381 1
Systematic Name YBR152W
Feature Type ORF, Verified
Description mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description Suppressor of PrP38-1 1
Chromosomal Location
ChrII:546376 to 547251 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SPP381 GO evidence and references
  View Computational GO annotations for SPP381
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
112 total interaction(s) for 71 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-purification: 2
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 39
  • Positive Genetic: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 291
Molecular Weight (Da) 33,772
Isoelectric Point (pI) 5.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:546376 to 547251 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..876 546376..547251 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000356
References cited on this page View Complete Literature Guide for SPP381
1) Lybarger S, et al.  (1999) Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Mol Cell Biol 19(1):577-84
2) Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30