SPO13/YHR014W Summary Help

Standard Name SPO13 1
Systematic Name YHR014W
Feature Type ORF, Verified
Description Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells (2, 3, 4)
Name Description SPOrulation 5
Chromosomal Location
ChrVIII:132047 to 132922 | ORF Map | GBrowse
Gbrowse
Genetic position: 11 cM
Gene Ontology Annotations All SPO13 GO evidence and references
  View Computational GO annotations for SPO13
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
overexpression
Resources
74 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 4
  • Co-localization: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 5
  • Phenotypic Enhancement: 11
  • Phenotypic Suppression: 8
  • Synthetic Lethality: 9
  • Synthetic Rescue: 28

Resources
Expression Summary
histogram
Resources
Length (a.a.) 291
Molecular Weight (Da) 33,294
Isoelectric Point (pI) 10.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:132047 to 132922 | ORF Map | GBrowse
SGD ORF map
Genetic position: 11 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..876 132047..132922 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001056
References cited on this page View Complete Literature Guide for SPO13
1) Klapholz, S. and Easton-Esposito, R.  (1985) Personal Communication, Mortimer Map Edition 9
2) Shonn MA, et al.  (2002) Spo13 protects meiotic cohesin at centromeres in meiosis I. Genes Dev 16(13):1659-71
3) Lee BH, et al.  (2002) Spo13 regulates cohesin cleavage. Genes Dev 16(13):1672-81
4) Sullivan M and Morgan DO  (2007) A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem 282(27):19710-5
5) Esposito MS, et al.  (1970) Conditional mutants of meiosis in yeast. J Bacteriol 104(1):202-10