SPO12/YHR152W Summary Help

SPO12 BASIC INFORMATION

Standard Name SPO12
Systematic Name YHR152W
Feature Type ORF, Verified
Description Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis (1, 2, 3)
Name Description SPOrulation
GO Annotations All SPO12 GO evidence and references
    View Computational GO annotations for SPO12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPO12 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions SPO12 All interactions details and references
117 total interaction(s) for 91 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 27
Genetic Interactions
  • Dosage Rescue: 23
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 12
  • Synthetic Rescue: 4
Sequence Information
ChrVIII:401437 to 401958 | ORF Map | GBrowse
Gbrowse
Genetic position: 83 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..522 401437..401958 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001195

SPO12 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPO12

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPO12]

1) Shah R, et al.  (2001) The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex. Genetics 159(3):965-80
2) Stegmeier F, et al.  (2002) Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108(2):207-20
3) Stern BM  (2003) FEARless in meiosis. Mol Cell 11(5):1123-5