Standard Name	SPO12
Systematic Name	YHR152W
Feature Type	ORF, Verified
Description	Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	SPOrulation 5

Chromosomal Location	ChrVIII:401434 to 401955 | ORF Map | GBrowse
	Genetic position: 83 cM

	View Computational GO annotations for SPO12
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	meiosis I (IMP) mitotic cell cycle (IEP, IGI) regulation of exit from mitosis (IGI)
Cellular Component
Manually curated	nucleolus (IDA) nucleus (IDA)

Classical genetics
null	Cdc14p-GFP distribution: abnormal
reduction of function	sporulation: abnormal
Large-scale survey
null	competitive fitness: decreased sporulation: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	168 total interaction(s) for 121 unique genes/features.
Physical Interactions	Affinity Capture-MS: 32 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Reconstituted Complex: 1 Two-hybrid: 27
Genetic Interactions	Dosage Rescue: 21 Negative Genetic: 37 Phenotypic Enhancement: 10 Phenotypic Suppression: 10 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 14 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:401434 to 401955 | ORF Map | GBrowse
	Genetic position: 83 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..522 401434..401955 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001195