Standard Name	SPO1
Systematic Name	YNL012W
Feature Type	ORF, Verified
Description	Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B (1, 2)
Name Description	SPOrulation 3

Chromosomal Location	ChrXIV:609686 to 611665 | ORF Map | GBrowse
	Genetic position: -1 cM

	View Computational GO annotations for SPO1
Molecular Function
Manually curated	phospholipase activity (ISS)
Biological Process
Manually curated	meiosis (IMP) spore membrane bending pathway (IGI, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) nucleus (IDA) prospore membrane (IDA)

Classical genetics
conditional	sporulation efficiency: absent sporulation efficiency: decreased
null	sporulation: absent
Large-scale survey
null	competitive fitness: increased resistance to tirapazamine: increased sporulation: absent sporulation efficiency: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	19 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 9 Phenotypic Suppression: 3 Positive Genetic: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:609686 to 611665 | ORF Map | GBrowse
	Genetic position: -1 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-07-14
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..105 609686..609790 2011-02-03 2000-07-14 Intron 106..189 609791..609874 2011-02-03 2000-07-14 CDS 190..1980 609875..611665 2011-02-03 2000-07-14
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (106 - 189)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004957