SPO1/YNL012W Summary Help

Standard Name SPO1 1
Systematic Name YNL012W
Feature Type ORF, Verified
Description Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B (2, 3)
Name Description SPOrulation 1
Chromosomal Location
ChrXIV:609686 to 611665 | ORF Map | GBrowse
Gbrowse
Genetic position: -1 cM
Gene Ontology Annotations All SPO1 GO evidence and references
  View Computational GO annotations for SPO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
unspecified
Resources
21 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • Co-purification: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 9
  • Phenotypic Suppression: 3
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 631
Molecular Weight (Da) 72,186
Isoelectric Point (pI) 8.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:609686 to 611665 | ORF Map | GBrowse
SGD ORF map
Genetic position: -1 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2000-07-14
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..105 609686..609790 2011-02-03 2000-07-14
Intron 106..189 609791..609874 2011-02-03 2000-07-14
CDS 190..1980 609875..611665 2011-02-03 2000-07-14
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004957
References cited on this page View Complete Literature Guide for SPO1
1) Esposito MS, et al.  (1970) Conditional mutants of meiosis in yeast. J Bacteriol 104(1):202-10
2) Tevzadze GG, et al.  (2000) Spo1, a phospholipase B homolog, is required for spindle pole body duplication during meiosis in Saccharomyces cerevisiae. Chromosoma 109(1-2):72-85
3) Maier P, et al.  (2008) The SpoMBe pathway drives membrane bending necessary for cytokinesis and spore formation in yeast meiosis. EMBO J 27(18):2363-74