Standard Name	SPN1 1
Systematic Name	YPR133C
Alias	IWS1 2
Feature Type	ORF, Verified
Description	Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype (1, 2, 3, 4)
Name Description	Suppresses Postrecruitment functions gene Number 1 1

Chromosomal Location	ChrXVI:797210 to 795978 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SPN1
Molecular Function
Manually curated	core RNA polymerase II binding transcription factor activity (IPI) RNA polymerase II transcription factor binding transcription factor activity (IPI)
Biological Process
Manually curated	poly(A)+ mRNA export from nucleus (IMP) regulation of transcription by chromatin organization (IMP, IPI) regulation of transcription elongation from RNA polymerase II promoter (IGI) regulation of transcription from RNA polymerase II promoter (IGI, IPI)
Cellular Component
Manually curated	nucleus (IC)

Classical genetics
conditional	his4-912(delta) accumulation: abnormal heat sensitivity: increased
null	inviable
Large-scale survey
conditional	colony sectoring: increased
null	competitive fitness: decreased haploinsufficient heat sensitivity: increased inviable
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased telomere length: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	110 total interaction(s) for 87 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 3 Affinity Capture-Western: 5 Co-crystal Structure: 1 PCA: 5 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 57 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:797210 to 795978 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1233 797210..795978 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006337