SPL2/YHR136C Summary Help

SPL2 BASIC INFORMATION

Standard Name SPL2
Systematic Name YHR136C
Feature Type ORF, Verified
Description Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm (1, 2, 3)
Name Description Suppressor of PLc1 deletion 1
GO Annotations All SPL2 GO evidence and references
    View Computational GO annotations for SPL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulatory Role
Regulatory modules predicted: cellcycle ( 257 )
Mutant Phenotype All SPL2 Phenotype details and references
Large-scale survey
null
Interactions SPL2 All interactions details and references
14 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Synthetic Lethality: 1
Sequence Information
ChrVIII:375103 to 374657 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..447 375103..374657 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001178

SPL2 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPL2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPL2]

1) Flick JS and Thorner J  (1998) An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae. Genetics 148(1):33-47
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Wykoff DD, et al.  (2007) Positive feedback regulates switching of phosphate transporters in S. cerevisiae. Mol Cell 27(6):1005-13