SPE4/YLR146C Summary Help

Standard Name SPE4 1
Systematic Name YLR146C
Feature Type ORF, Verified
Description Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid (2, 3)
Name Description SPErmidine auxotroph 4
Chromosomal Location
ChrXII:433725 to 432823 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SPE4 GO evidence and references
  View Computational GO annotations for SPE4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
Resources
38 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Biochemical Activity: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 21
  • Phenotypic Enhancement: 1
  • Positive Genetic: 7
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 300
Molecular Weight (Da) 34,090
Isoelectric Point (pI) 4.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:433725 to 432823 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..903 433725..432823 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004136
References cited on this page View Complete Literature Guide for SPE4
1) Cohn MS, et al.  (1980) Regulatory mutations affecting ornithine decarboxylase activity in Saccharomyces cerevisiae. J Bacteriol 142(3):791-9
2) Hamasaki-Katagiri N, et al.  (1998) Spermine is not essential for growth of Saccharomyces cerevisiae: identification of the SPE4 gene (spermine synthase) and characterization of a spe4 deletion mutant. Gene 210(2):195-201
3) White WH, et al.  (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800
4) Whitney PA and Morris DR  (1978) Polyamine auxotrophs of Saccharomyces cerevisiae. J Bacteriol 134(1):214-20