SPE3/YPR069C Summary Help

Standard Name SPE3 1
Systematic Name YPR069C
Feature Type ORF, Verified
Description Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells (2, 3)
Name Description SPErmidine auxotroph 1
Chromosomal Location
ChrXVI:685437 to 684556 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SPE3 GO evidence and references
  View Computational GO annotations for SPE3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
unspecified
Resources
108 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 68
  • Phenotypic Enhancement: 1
  • Positive Genetic: 15
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 293
Molecular Weight (Da) 33,324
Isoelectric Point (pI) 5.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:685437 to 684556 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..882 685437..684556 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006273
References cited on this page View Complete Literature Guide for SPE3
1) Whitney PA and Morris DR  (1978) Polyamine auxotrophs of Saccharomyces cerevisiae. J Bacteriol 134(1):214-20
2) Hamasaki-Katagiri N, et al.  (1997) Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase). Gene 187(1):35-43
3) White WH, et al.  (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800