Standard Name	SPE2
Systematic Name	YOL052C
Feature Type	ORF, Verified
Description	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically (1, 2)
Name Description	SPErmidine auxotroph 3

Chromosomal Location	ChrXV:233636 to 232446 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -58 cM

	View Computational GO annotations for SPE2
Molecular Function
Manually curated	adenosylmethionine decarboxylase activity (IDA)
Biological Process
Manually curated	pantothenate biosynthetic process (IMP) spermidine biosynthetic process (IMP) spermine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	spermidine and methylthioadenosine biosynthesis spermine and methylthioadenosine biosynthesis superpathway of methionine salvage pathway superpathway of polyamine biosynthesis

Classical genetics
null	auxotrophy spermidine accumulation: absent putrescine accumulation: increased spermine accumulation: absent
Large-scale survey
null	auxotrophy polyphosphate accumulation: abnormal chronological lifespan: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	86 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Biochemical Activity: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 50 Phenotypic Enhancement: 2 Phenotypic Suppression: 4 Positive Genetic: 14 Synthetic Growth Defect: 8 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:233636 to 232446 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -58 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1191 233636..232446 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005412