Standard Name	SPE1 (see Nomenclature conflict Note)
Systematic Name	YKL184W
Alias	ORD1 , SPE10 1
Feature Type	ORF, Verified
Description	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation (2, 3, 4, 5)
Name Description	SPErmidine auxotroph 6

Chromosomal Location	ChrXI:96757 to 98157 | ORF Map | GBrowse
	Genetic position: -130.3 cM

	View Computational GO annotations for SPE1
Molecular Function
Manually curated	ornithine decarboxylase activity (IDA)
Biological Process
Manually curated	pantothenate biosynthetic process (IMP) putrescine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	putrescine biosynthesis superpathway of polyamine biosynthesis

Classical genetics
null	auxotrophy putrescine accumulation: absent spermidine accumulation: absent spermine accumulation: absent reactive oxygen species accumulation: increased chronological lifespan: decreased necrotic cell death: increased COX4-EGFP accumulation: increased GFP-Rap1 distribution: abnormal pseudohyphal growth: absent
unspecified	resistance to enzymatic treatment: decreased
Large-scale survey
null	auxotrophy competitive fitness: decreased haploinsufficient resistance to chloroquine: decreased resistance to glycolaldehyde: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	284 total interaction(s) for 204 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 3 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 178 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Positive Genetic: 79 Synthetic Growth Defect: 8 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:96757 to 98157 | ORF Map | GBrowse
	Genetic position: -130.3 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1401 96757..98157 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001667