SPC24/YMR117C Summary Help

Standard Name SPC24
Systematic Name YMR117C
Feature Type ORF, Verified
Description Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p (1, 2, 3)
Name Description Spindle Pole Component
Chromosomal Location
ChrXIII:501891 to 501250 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SPC24 GO evidence and references
  View Computational GO annotations for SPC24
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
conditional
reduction of function
Large-scale survey
conditional
null
reduction of function
repressible
Resources
312 total interaction(s) for 186 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-Western: 22
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 4
  • PCA: 7
  • Reconstituted Complex: 10
  • Two-hybrid: 127

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 6
  • Negative Genetic: 57
  • Positive Genetic: 1
  • Synthetic Growth Defect: 23
  • Synthetic Lethality: 21
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 213
Molecular Weight (Da) 24,604
Isoelectric Point (pI) 4.69
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:501891 to 501250 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..642 501891..501250 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004723
References cited on this page View Complete Literature Guide for SPC24
1) Wigge PA and Kilmartin JV  (2001) The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 152(2):349-60
2) Janke C, et al.  (2001) The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J 20(4):777-91
3) He X, et al.  (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2):195-206