Standard Name	SPC110 1
Systematic Name	YDR356W
Alias	XCM1 2 , NUF1 3
Feature Type	ORF, Verified
Description	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner (2, 3, 4, 5, 6)
Name Description	Spindle Pole Component 1

Chromosomal Location	ChrIV:1186107 to 1188941 | ORF Map | GBrowse

	View Computational GO annotations for SPC110
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	karyogamy involved in conjugation with cellular fusion (IGI, IMP) microtubule nucleation (IPI)
Cellular Component
Manually curated	central plaque of spindle pole body (IDA) inner plaque of spindle pole body (IDA)

Classical genetics
conditional	heat sensitivity: increased
null	respiratory growth: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal colony sectoring: increased
null	filamentous growth: decreased invasive growth: absent inviable
reduction of function	competitive fitness: normal
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	201 total interaction(s) for 116 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 2 Affinity Capture-Western: 16 Biochemical Activity: 5 Co-localization: 1 Co-purification: 40 FRET: 10 Reconstituted Complex: 9 Two-hybrid: 20
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 4 Dosage Rescue: 15 Negative Genetic: 2 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 50 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1186107 to 1188941 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2835 1186107..1188941 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002764