Standard Name	SOH1 1
Systematic Name	YGL127C
Alias	MED31 2
Feature Type	ORF, Verified
Description	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits (2, 3, 4, 5)
Name Description	Suppressor Of Hpr1 1

Chromosomal Location	ChrVII:270775 to 270392 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SOH1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	DNA repair (IPI) meiotic gene conversion (IMP) meiotic sister chromatid segregation (IMP) transcription from RNA polymerase II promoter (IDA, IGI)
Cellular Component
Manually curated	core mediator complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	tellurium atom accumulation: increased meiosis: abnormal resistance to hydroxyurea: decreased resistance to tellurite: decreased utilization of carbon source: decreased
Large-scale survey
null	auxotrophy glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased resistance to oleate: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to neomycin: decreased resistance to streptomycin: decreased resistance to hydroxyurea: decreased resistance to ethanol: decreased resistance to sodium arsenite: decreased resistance to propolis extract: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to dimethyl sulfoxide: decreased resistance to lovastatin: decreased resistance to selenomethionine: increased resistance to sorbate: decreased stress resistance: increased telomere length: decreased transposable element transposition: increased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	559 total interaction(s) for 323 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 2 Affinity Capture-Western: 13 Co-crystal Structure: 1 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 15
Genetic Interactions	Negative Genetic: 344 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 50 Synthetic Growth Defect: 51 Synthetic Lethality: 24 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:270775 to 270392 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..384 270775..270392 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003095