SNX3/YOR357C Summary

Standard Name	SNX3 1
Systematic Name	YOR357C
Alias	GRD19 2
Feature Type	ORF, Verified
Description	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p (1, 2, 3 and see Summary Paragraph)
Name Description	Sorting NeXin 1

Chromosomal Location	ChrXV:1009712 to 1009224 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All SNX3 GO evidence and references

	View Computational GO annotations for SNX3
Molecular Function
Manually curated	phosphatidylinositol-3-phosphate binding (IDA)
Biological Process
Manually curated	late endosome to Golgi transport (IMP) protein localization (IMP)
Cellular Component
Manually curated	cytosol (IDA) endosome (IDA)

Mutant phenotypes All SNX3 Phenotype evidence and references

Classical genetics
null	metal resistance: decreased metal resistance: increased
Large-scale survey
null	rubidium(1+) accumulation: decreased competitive fitness: decreased Fus-Mid-GFP distribution: abnormal resistance to hygromycin B: decreased resistance to wortmannin: normal resistance to dimethyl sulfoxide: decreased resistance to sirolimus: decreased resistance to nickel sulfate: increased resistance to L-canavanine: increased viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All SNX3 Interaction evidence and references

	37 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 3 PCA: 2 Two-hybrid: 12
Genetic Interactions	Negative Genetic: 7 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 4
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DRYGIN \| GeneMANIA \| InterologFinder \| YeastRC Two-Hybrid

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All SNX3 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| AspGD Homologs \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXV:1009712 to 1009224 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..489	1009712..1009224	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000005884

SUMMARY PARAGRAPH for SNX3

Snx3p contains the PX domain found in human SNX1 (Sorting Nexin-1). Localized predominantly to the cytosol, a minor amount of Snx3p associates with membranes. In vps27 mutant cells, Snx3p-HA localizes in the prevaculoar compartment.

Last updated: 2005-12-07

References cited on this page View Complete Literature Guide for SNX3

1)	Haft CR, et al. (1998) Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol 18(12):7278-87
2)	Voos W and Stevens TH (1998) Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p. J Cell Biol 140(3):577-90
3)	Hettema EH, et al. (2003) Retromer and the sorting nexins Snx4/41/42 mediate distinct retrieval pathways from yeast endosomes. EMBO J 22(3):548-57