Standard Name	SNU66
Systematic Name	YOR308C
Feature Type	ORF, Verified
Description	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 (1, 2, 3)
Name Description	Small NUclear ribonucleoprotein associated 1

Chromosomal Location	ChrXV:896387 to 894624 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SNU66
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	maturation of 5S rRNA (IGI, IMP) mRNA splicing, via spliceosome (IMP, IPI)
Cellular Component
Manually curated	U4/U6 x U5 tri-snRNP complex (IDA)

Classical genetics
null	pre-5S rRNA accumulation: increased cold sensitivity: increased 60S ribosomal subunit accumulation: decreased resistance to sirolimus: increased
Large-scale survey
null	competitive fitness: decreased resistance to tunicamycin: increased resistance to dimethyl sulfoxide: decreased resistance to methyl methanesulfonate: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to neomycin: decreased resistance to sirolimus: increased transposable element transposition: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	295 total interaction(s) for 155 unique genes/features.
Physical Interactions	Affinity Capture-MS: 117 Affinity Capture-Western: 13 Co-crystal Structure: 1 Co-purification: 3 Protein-RNA: 1 Reconstituted Complex: 2 Two-hybrid: 10
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 102 Phenotypic Enhancement: 1 Positive Genetic: 19 Synthetic Growth Defect: 16 Synthetic Lethality: 8 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:896387 to 894624 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1764 896387..894624 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005835