SNF3/YDL194W Summary Help

Standard Name SNF3 1, 2, 3
Systematic Name YDL194W
Feature Type ORF, Verified
Description Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication (4, 5, 6, 7, 8, 9)
Name Description Sucrose NonFermenting 10
Chromosomal Location
ChrIV:111580 to 114234 | ORF Map | GBrowse
Genetic position: -104 cM
Gene Ontology Annotations All SNF3 GO evidence and references
  View Computational GO annotations for SNF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
reduction of function
Large-scale survey
58 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 11
  • Negative Genetic: 10
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 11

Expression Summary
Length (a.a.) 884
Molecular Weight (Da) 96,718
Isoelectric Point (pI) 5.13
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:111580 to 114234 | ORF Map | GBrowse
Genetic position: -104 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2655 111580..114234 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000002353
References cited on this page View Complete Literature Guide for SNF3
1) Neigeborn L and Carlson M  (1984) Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics 108(4):845-58
2) Neigeborn L, et al.  (1986) Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations. Mol Cell Biol 6(11):3569-74
3) Celenza, J. and Carlson, M.  (1989) Personal Communication, Mortimer Map Edition 10
4) Vagnoli P, et al.  (1998) The C-terminal domain of Snf3p mediates glucose-responsive signal transduction in Saccharomyces cerevisiae. FEMS Microbiol Lett 160(1):31-6
5) Ozcan S, et al.  (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc Natl Acad Sci U S A 93(22):12428-32
6) Ko CH, et al.  (1993) Roles of multiple glucose transporters in Saccharomyces cerevisiae. Mol Cell Biol 13(1):638-48
7) Ozcan S, et al.  (1998) Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. EMBO J 17(9):2566-73
8) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
9) Dietvorst J, et al.  (2010) Amino acid residues involved in ligand preference of the Snf3 transporter-like sensor in Saccharomyces cerevisiae. Yeast 27(3):131-8
10) Carlson M, et al.  (1981) Mutants of yeast defective in sucrose utilization. Genetics 98(1):25-40