SNC1/YAL030W Summary Help

Standard Name SNC1 1
Systematic Name YAL030W
Feature Type ORF, Verified
Description Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Suppressor of the Null allele of CAP 1
Chromosomal Location
ChrI:87286 to 87752 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SNC1 GO evidence and references
  View Computational GO annotations for SNC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
115 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 33
  • Co-crystal Structure: 2
  • Co-fractionation: 3
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 6
  • Dosage Rescue: 13
  • Negative Genetic: 13
  • Phenotypic Enhancement: 6
  • Positive Genetic: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 12
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 117
Molecular Weight (Da) 13,201
Isoelectric Point (pI) 8.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:87286 to 87752 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..102 87286..87387 2011-02-03 1996-07-31
Intron 103..215 87388..87500 2011-02-03 1996-07-31
CDS 216..467 87501..87752 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000028
References cited on this page View Complete Literature Guide for SNC1
1) Gerst JE, et al.  (1992) SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proc Natl Acad Sci U S A 89(10):4338-42
2) David D, et al.  (1998) Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast. J Cell Biol 143(5):1167-82
3) Protopopov V, et al.  (1993) Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell 74(5):855-61
4) Gurunathan S, et al.  (2000) Yeast exocytic v-SNAREs confer endocytosis. Mol Biol Cell 11(10):3629-43
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61